After a self-imposed hiatus following the tragic events of the last shuttle mission, NASA prepares to launch the Icarus on a simple mission to help restore the nation's confidence in the space program. But their worst fears are realized when it is discovered that something has gotten aboard the shuttle, something ferocious, something with fangs and a taste for blood. Written by Steve Niles and Dan Wickline, it was drawn by Milx.
"Dead Billy Dead", written by Steve Niles and illustrated by Kody Chamberlain. This serialized story featured a young man named Billy who was turned into a vampire and later kidnapped, along with his girlfriend Maggie, by a vampire-obsessed scientist. Meanwhile, Goodis, a police officer whom Maggie had called when approached by the vampiric Billy, discovers Stella Olemaun's book.
"Juarez or Lex Nova and the Case of the 400 Dead Mexican Girls", written by Matt Fraction and illustrated by Ben Templesmith. This story depicted Lex Nova's investigation of the disappearance of hundreds of girls in Juarez, Mexico. A group of vampires called the Zero Family Circus arrives in Mexico at the same time, believing the deaths to be caused by an estranged vampire.